Hormonal Determinants of Mammographic Density
Annual summary rept. 1 Aug 2002-31 Jul 2005
PITTSBURGH UNIV PA
Pagination or Media Count:
Hormone Replacement Therapy HRT has been shown to increase breast cancer risk as well as to increase breast density. Breast density, a reflection of the histologic composition of the breast, is one factor shown to affect mammographic sensitivity and specificity, and it is predictive of breast cancer risk. Thus, the use of HRT, through its effect on breast density, may compromise the well-established reduction in mortality gained by mammographic screening. However, not all women on HRT will experience an increase in breast density. We propose a novel hypothesis to explain in part the individual variability in breast density seen among women on HRT differences in breast density are associated with differences in estrogen metabolism, and this association may be attenuated by individual factors such as body mass Index and HRT regimen. Our work and the work of others provide compelling evidence to support this hypothesis. To date 212 cases and 399 healthy women have been enrolled in this study.
- Anatomy and Physiology
- Medicine and Medical Research