NSAIDS and the Osteogenic Response to Mechanical Stress in Premenopausal Women
Annual rept. 20 Sep 2004-19 Sep 2005
COLORADO UNIV HEALTH SCIENCES CENTER AURORA CO
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This is a study of the effects of ibuprofen, a non-steroidal anti-inflammatory drug NSAID, on the osteogenic response to 9 months of exercise training in healthy, premenopausal women, aged 21 to 40 years N102. The hypotheses are H1a taking short-acting NSAIDS before exercise will diminish increases in bone mineral density BMD in response to exercise training H1b taking short-acting NSAIDS after exercise will not diminish the increases in BMD in response to exercise training. Participants take either ibuprofen 4OOmg or placebo capsules before and after each exercise session. Women are randomized to three treatment arms NSAID before exercise, placebo after exercise NSAIDplacebo n34 placebo before exercise, NSAID after exercise placeboNSAID n34 and placebo before exercise, placebo after exercise placeboplacebo n34. One hundred thirteen women completed baseline testing and were randomized to treatment 62 women have completed the study. Final follow-up testing and sample analyses will be completed in the next 4-5 months. These studies could lead to the development of new strategies to reduce the incidence of, and treatment for, stress fractures that occur in response to vigorous physical activity.
- Medicine and Medical Research
- Stress Physiology