New Approaches in SPECT Breast Imaging
Annual summary rept. 1 Jul 2001-30 Jun 2005
DUKE UNIV DURHAM NC
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The primary objective of this research is to develop new techniques in single photon emission computed tomography SPECT breast cancer imaging providing improved detection and characterization of early stage breast cancer. Projection data were acquired by implementing a tiltable SPECT system on a breast and torso phantom. The data were reconstructed with both an ordered subset expectation maximization OSEM algorithm and a filtered backprojection FPP algorithm with a ramp filter. Results indicated that the OSEM values for SNR and contrast were higher at all tilt angles and may offer better shape and uniform activity distribution of the breast compared to FBP images. Also, by using a tilted head SPECT system, the radius of rotation decreases and the chest wall near the breast can be adequately imaged. This results in increased resolution and sensitivity. A pinhole collimator is advantageous in imaging a breast due to its ability to get close to the breast and achieve a small radius of rotation, though lead shielding was ineffective in eliminating background activity from the myocardium and liver. Statistical analysis of differing acquisition geometries for incomplete circular orbits for breast pinhole SPECT imaging have shown greater reduction in sampling artifacts.
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