Testing Whether Defective Chromatin Assembly in S-Phase Contributes to Breast Cancer
Final rept. 30 Sep 2002-29 Sep 2005
FOX CHASE CANCER CENTER PHILADELPHIA PA
Pagination or Media Count:
We showed that defects in chromatin assembly trigger DNA damage, a potent source of genome instability and cause of human cancers. Although we failed to make a specific link between defects in chromatin assembly and breast cancer, our survey was not exhaustive and leaves open the possibility that future studies might reveal such a link. Second, we showed that the histone chaperones HIRA and ASF 1 a drive formation of specialized domains of facultative heterochromatin in senescent cells and senescence-associated cell cycle exit. Although the funding period has ended, my lab is continuing to investigate whether genetic alterations of HIRA and ASF 1 a and other factors in this pathway contribute to cancers of breast and other tissues.
- Anatomy and Physiology