Breast Cancer Prevention by Inducing Apoptosis in DCIS Using Breast Ductal Lavage
Annual rept. 1 Sep 2004-31 Aug 2005
WAKE FOREST UNIV WINSTON-SALEM NC
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Although great strides have been made in breast cancer screening and treatment, it remains the second highest cause of cancer-related deaths for women in the United States. Current prevention focuses on oral administration of tamoxifen which decreases breast cancer incidence but increases the risk for secondary uterine cancer. In addition, tamoxifen may not be effective in preventing those lesions that are estrogen receptor ER negative based on its primary function of suppressing cell proliferation by blocking the estrogen receptor. We hypothesize that programmed cell death is dysregulated in premalignant and malignant breast cells which permits both ER-positive and ER-negative cells to avoid cell death. We intend to investigate whether treating premalignant breast cells with a molecular genetic-based agent may be effective alone or in concert with tamoxifen treatment to induce cell death in both ER-positive and ER-negative cells. Ultimately, we envision delivering genetic- based preventive agents andor tamoxifen directly to the breast ductal lobe of these high risk individuals thus eliminating any potential for tamoxifen-induced uterine cancers.
- Medicine and Medical Research