Effects of Naturally-Occurring Estrogen-Fatty Acid Esters on Mammary Cell Growth and Carcinogenesis in Female Rats
Annual summary rept. 1 Jun 2002-31 May 2005
SOUTH CAROLINA UNIV RESEARCH FOUNDATION COLUMBIA
Pagination or Media Count:
This is the final report for the Predoctoral Taineeship Award No. DAMD17-02-1-0567. The studies described in the original grant proposal have been completed. The major findings included the following i We demonstrated, for the first time, that the naturally-occurring estrogen fatty acid esters have a differential, strong mitogenic effect in the fat-rich mammary tissues, and this effect was not observed with estradiol. ii We showed that the endogenous estrogen fatty acid esters are pathogenically more important than estradio for the selective induction of mammary tumor formation. iii We found that the estrogen esterase activity is higher in the breast tissue than in the uterus, which provides the bases for our hypothesis, the endogenous estrogen-fatty acid esters are mammary-selective estrogens for stimulation of cell growth and cancer formation.
- Medicine and Medical Research