Accession Number:

ADA443582

Title:

A CpG Oligonucleotide Can Protect Mice From a Low Aerosol Challenge Dose of Burkholderia mallei

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Report Date:

2006-03-01

Pagination or Media Count:

6.0

Abstract:

Oligonucleotides containing CpG motifs were tested for protective efficacy in a mouse Burkholderia mallei aerosol challenge model. CpG 7909 protected all mice from death up to 7 weeks after challenge. The lungs from treated mice were protected from infection. Preexposure therapy may protect victims of a biological attack from glanders.

Subject Categories:

  • Biochemistry
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE