Effects of Low Level Radiation exposure on Neurogenesis and Cognitive Function: Mechanisms and Prevention
Final rept. 1 Aug 2001-1 Aug 2005
CALIFORNIA UNIV SAN FRANCISCO
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Studies were carried out to investigate the radiation response of neural precursor cells in vitro and in vivo, to determine the role of reactive oxygen species ROS in the reactions of those cells, and to determine if antioxidant treatment could modify those responses. Our data show that proliferating precursor cells and their progeny are extremely sensitive to lowmoderate x-ray doses 2-10 Gy, and that ROS play a major role in the sensitivity on these cells and may act in concert with p53 and cell cycledependent processes. In addition, conditions of reduced cell density, such as that seen after radiation exposure of the dentate subgranular zone, are associated with increased ROS, which may stimulate proliferation in surviving cells. Modulating ROS using antioxidant compounds may provide a means to control proliferation in damaged cells allowing for repair and recovery after radiation injury. We have begun to address specific mechanistic factors that are not only associated with oxidative processes, but that may provide additional targets for interventional treatment. The ability to ameliorate the radiation effects on neural precursor cells may provide a potential protective strategy for individuals exposed to unplanned exposure to lowmoderate doses of irradiation.
- Medicine and Medical Research
- Stress Physiology