Mouse Models for Bone Research to Assess Military Stress Fracture Risk
Final rept. 30 Sep 2003-31 Mar 2005
JACKSON LAB BAR HARBOR ME
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Researchers at The Jackson Laboratory identified a strong correlation between lean body mass and bone mineral content in some but not all inbred strains of mice. Research projects reported herein, with Dr. Donahue as Principal Investigator, capitalize on the newly established Mouse Phenome Project to expand the publicly available Mouse Phenome Database and analytical tools for bone morphology and associated phenotypes in target strains Dr. Bogue, Part I extend the on-going research defining heritable musclebone relationships Drs. Donahue, Beamer, Rosen, and Bouxsein, Part TI and initiate genetic analyses to establish characteristics of musclebone relationships based on systematic diallele crosses among strains defined in Dr. Donahues investigations Dr. Churchill, Part III. The data and conclusions presented in this report provide insight into the etiology and heritability of bone strength, and thus benefit readiness and retention of U.S. Armed Forces by establishing a means to identify male and female recruits at high risk for fracturing during basic training and in combat situations.
- Medicine and Medical Research