A Viable Neuroprotection Strategy Following Soman-induced Status Epilepticus
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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The present study examined the neuroprotective effectiveness of dantrolene in the prevention of soman-induced SRBD. Dantrolene is FDA approved for the treatment of malignant hyperthermia. The decision to consider this compound is based on its well-known mode of action in preventing the release of calcium from intracellular stores. In addition, we assessed possible synergistic overlap in the neuroprotective effectiveness of combined dantrolene and diazepam co-treatment. The combined neuroprotective effectiveness of diazepamdantrolene is compared with that of diazepamHU-211 dexanabinol. The present results provide strong evidence that, by blocking the release of calcium from intracellular stores, dantrolene synergistically augmented the neuroprotection produced by diazepam alone.