Accession Number:

ADA443565

Title:

A Viable Neuroprotection Strategy Following Soman-induced Status Epilepticus

Descriptive Note:

Technical rept.

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

2003-12-01

Pagination or Media Count:

20.0

Abstract:

The present study examined the neuroprotective effectiveness of dantrolene in the prevention of soman-induced SRBD. Dantrolene is FDA approved for the treatment of malignant hyperthermia. The decision to consider this compound is based on its well-known mode of action in preventing the release of calcium from intracellular stores. In addition, we assessed possible synergistic overlap in the neuroprotective effectiveness of combined dantrolene and diazepam co-treatment. The combined neuroprotective effectiveness of diazepamdantrolene is compared with that of diazepamHU-211 dexanabinol. The present results provide strong evidence that, by blocking the release of calcium from intracellular stores, dantrolene synergistically augmented the neuroprotection produced by diazepam alone.

Subject Categories:

  • Biochemistry
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE