Accession Number:

ADA443564

Title:

Effects of Prednisolone Acetate on Ocular Sulfur Mustard Injury in a Rabbit Model

Descriptive Note:

Technical rept. Apr-Sep 2002

Corporate Author:

ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

Report Date:

2003-12-01

Pagination or Media Count:

22.0

Abstract:

Eye injury from HD sulfur mustard exposure continues to remain a threat to soldiers in the battlefield. This study was designed to explore the effects of Pred-Forte prednisolone in treating ocular HD injury. Sixteen female New Zealand White rabbits were exposed to 0.51 mg of undiluted HD as a liquid droplet. One group n8 received 2 drops of Pred-Forte into the eye every 10 minutes for the first 30 minutes postexposure, then every 30 minutes for 2 hours, after which treatments were given three times daily tid. The control group of animals n7 received 2 drops of Artificial Tears. Eyes of rabbits were evaluated and scored weekly for 56 weeks, then at 12, 13 and 16 weeks. Measurements included slit lamp evaluation, corneal thickness Pachymetry, and modified ocular severity score MOSS. Lesions or ulcers resulting in corneal perforations developed within the first 34 weeks in 9 out of 15 rabbits. Treatments were discontinued at 3 weeks however, observations continued to 16 weeks. Adverse reactions were attributed to treatment effect, inexperienced operators HD andor both. The use of different applications of HD to the eye should also be considered to eliminate variability seen with the droplet method.

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology
  • Space Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE