Accession Number:

ADA443250

Title:

Molecular Effects of I3C/DIM in Prostate Cancer Cells

Descriptive Note:

Annual rept. 1 Apr 2004-31 Mar 2005

Corporate Author:

WAYNE STATE UNIV DETROIT MI

Personal Author(s):

Report Date:

2005-04-01

Pagination or Media Count:

47.0

Abstract:

Our previous data have shown that 13C inhibits cell growth and induces apoptosis in cancer cells. We have also observed a reduction in the activated Akt and the activity of NF-kappaB in prostate cancer cells treated with I3C. By gene transfection and kinase assay, we have found that the inhibition of NF-kappaB by I3C and DIM was partly mediated through the inactivation of Akt. 13C and DIM inhibited phosphorylation of Akt, inactivated NF-KB, and regulated the expression of genes related to cell growth and apoptosis.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE