Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland
Annual rept. 1 Mar 2004-28 Feb 2005
MONTREAL GENERAL HOSPITAL (QUEBEC) RESEARCH INST
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At the Montreal site, 195 participants have consented to participate and their blood was drawn. We have another 15 men that have agreed to participate and their blood will be drawn in the next few months. We have recruited a total of 42 controls. The pedigrees for all controls and cases have been drawn. Ishihara charts were shown to all cases and controls and the results were recorded. At the Switzerland site, case ascertainment is underway. To date, an additional three urologist and a radio-oncologist have given their support to this project. 319 patients have been contacted and 102 have had a consultation with a DNA sampling. An additional 28 men have given their consent to participate at the Sion site. As well as continuing to look at the X chromosome for relevant markers, we have genotyped 11 microsatellite markers, spanning 34 megabases on chromosome 7, in approximately 140 of our cases. We observed suggestive differences between cases and controls for two markers located approximately 2.75 megabases apart at 7q11.23 D7S2518 and D7S2204 . We also conducted the first phase of a SNP discovery project. We resequenced CHEK2 in 75 Ashkenazi Jewish individuals 25 prostate cancer, 25 breast cancer and 25 controls. We identified 5 novel SNPs. These are now under detailed investigation. Finally, we completed and published our study of the putative prostate cancer gene, MSR1.
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