The Intramuscular Toxicity of Soman in the African Green Monkey
Technical rept., 6 Jan-1 Mar 2004
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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The present study established the toxicity of the nerve agent soman in the African green monkey Chlorocebus aethiops. Seven male African green monkeys were implanted with telemetry devices to monitor electro-encephalographic EEG activity. The up-down method of Dixon and Massey 1981 was used to estimate the LDsub-50. Soman was injected IM in the calf muscle. One subject was given 5.01 ugkg soman toxic signs fasciculations, tremors, salivation developed within 5 min with tonic-clonic motor convulsions and EEG seizure beginning shortly thereafter and persisting for 1 hr. Toxic signs diminished over 6 hr and the animal recovered. Three animals were exposed to 6.31 ugkg soman. Similar toxic signs developed seizures and convulsions persisted 4-5 hr. Two animals recovered while the other animal developed spontaneous seizureconvulsions and failed to take nourishment. Three animals were exposed to 7.94 ugkg soman. All developed severe seizures and motor convulsions accompanied by profuse salivation. Two animals died in 30 min, the third died 5 hr after exposure. The 48-hr IM LDsub-50 of soman was calculated to be 7.15 ugkg. The African green monkey responds to soman exposure with the same progression of toxic signs and at similar dose levels as reported for rhesus monkeys.
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare