Genes Involved in Oxidation and Prostate Cancer Progression
Annual rept. 1 Jan 2004-31 Dec 2005
JOHNS HOPKINS UNIV BALTIMORE MD
Pagination or Media Count:
We are evaluating the association of polymorphisms in genes involved in the generation of reactive oxygen species, the detoxification of reactive oxygen species, and the repair of oxidative DNA damage with prostate cancer progression. After several meetings among the collaborators to define cases and controls, we have selected from among all men who underwent radical prostatectomy for clinically organ-confined prostate cancer at Johns Hopkins between 1993 and 2004 the PSA era all men who have progressed to biochemical failure, overt metastases, or death from prostate cancer. From among the cohort of men who underwent prostatectomy we selected controls using incidence density sampling. The total number of eligible cases was 524. We selected an equal number of controls who were closely matched to the cases on age, race, and pathologic stage and grade. We are cataloging those cases and controls for whom DNA has already been extracted and are identifying from our archives frozen seminal vesicles and paraffin-embedded unaffected lymph nodes from which we will extract DNA. Selection of genes and polymorphisms in those genes will be done close in time to genotyping to capitalize on the emerging HapMap. We expect to begin genotyping by late summer statistical analysis to follow. No results are available yet.
- Medicine and Medical Research