Investigation of Soman Adducts of Human Hemoglobin by Liquid Chromatography
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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Verification of exposure to chemical agents is a requirement of the intelligence, depot, and demilitarization communities to confirm claims of exposure to chemical warfare agents. Improving current analytical methods and developing novel methods to verify chemical agent exposure are vital, considering the increased threat of chemical agent use and therefore the possibility of large numbers and types of biomedical samples that a relatively small number of labs must analyze. The current study focuses on development of an analytical method to determine past exposure to soman GD by identifying GD adducts of human hemoglobin Hb. Although previous studies have indicated that GD does bind to the tyrosine residue in human albumin, no such adduct was found for GD and human hemoglobin.
- Chemical, Biological and Radiological Warfare