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Bone Mineral Density, Sex Steroid Genes, Race, and Prostate Cancer Risk

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Annual rept. 1 Sep 2004-31 Aug 2005

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The goal of this project is to determine whether bone mineral density assumed to be an integrated marker of sex steroid hormone exposure is a risk factor for prostate cancer and 2 to identify prostate cancer susceptibility alleles among genes in the sex steroid pathway. To address these aims, we are undertaking a case-control study of African American and Caucasian men in Pittsburgh, PA and Birmingham, AL. As of 73104, 163 Caucasian and 19AA cases, 159 Caucasin and 14 AA controls with PSA 3.0 ngmL frequency matched by age and race to Hip, spine and total body BMD is measured by Dual-energy X-ray Absorptiometry DXA on all participants. Blood specimens have been used to isolate DNA on 255 subjects. Polymerase Chain Reaction PCR techniques are being used to determine allelic distributions of genotypes for sex steroid metabolism, biosynthesis and action genes. Risk factor data are obtained by an in-person interview and are immediately scanned into the study database. Caucasian recruitment has been completed. AA recruitment is ongoing. Upon completion of AA recruitment and data collection, we will evaluate the rote of BMD and candidate genotypes in prostate cancer risk by race. We will further examine the interaction between BMD and genotypes to evaluate the hormonal environment - gene interaction and its effect on prostate cancer risk.

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  • Medicine and Medical Research

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