The Role of Stat3 Activation in Androgen Receptor Signaling and Prostate Cancer
Annual rept. 1 Jul 2004-30 Jun 2005
HEALTH RESEARCH INC BUFFALO NY
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Most prostate cancer patients respond initially to androgen ablation and antiandrogen therapy. However, virtually all patients will relapse due to acquisition of the growth of the androgen-independent tumor cells. The molecular mechanism characterizing prostate cancer progression from androgen-dependence to androgen independence is incompletely understood. We propose that Signal Transducers and Activators of Transcription 3 Stat3 both regulates the expression of Stat3 target genes, and interacts with AR in prostate cancer cells. The experiments proposed in this application are based upon the hypothesis that Stat3 activation alters androgen receptor signaling pathways, that in turn results in the loss of growth control in prostate cancer cells. We propose to determine the consequence of Stat3 activation in prostate cancer cell growth and to determine the molecular basis of Stat3 interactions with androgen receptor signaling.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology