Testing of WW-85
INOTEK PHARMACEUTICALS CORP BENERLY MA
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The current document provides information on the development of WW-85, an ultrapotent catalytic anti-oxidant as a radioprotectant countermeasure. Radiation injury induces the generation of multiple reactive oxygen and nitrogen radicals in living tissues which then trigger oxidative peroxidative nitrosative and other forms of damage to proteins lipids and nucleic acids in the cells. Data in the literature indicate that neutralization of these oxidant and free radical reactions and chain reactions is of protective value during radiation injury. However, the practical hurdles that hamper the introduction of a clinically useful anti-oxidant are that most available anti-oxidants such as Vitamin C Vitamin E thiol-based compounds are relatively slow reacting and do not neutralize fast-reacting species. In addition, effective concentrations of these compounds are difficult to be reached in living tissues. Preclinical data with radioprotectant anti-oxidants amifostine melatonin demonstrate a relatively modest effect.