BRCC36, A Novel Subunit of a BRCA1 E3 Ubiquitin Ligase Complex: Candidates for BRCA3
Annual rept., 15 May 2004-14 May 2005
FOX CHASE CANCER CENTER PHILADELPHIA PA
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Breast cancer is a genetically heterogeneous disease, and multiple genes remain to be identified among non-BRCA1 and BRCA2 breast cancer-prone families. This statement is supported by the evidences that BRCA1 and BRCA2 mutations are associated with 20 to 60 of hereditary breast cancer families, which is less than originally estimated, especially in population-based studies. There is mounting evidence which suggests that there may be additional, less prevalent breast cancer susceptibility genes however the identification of these genes remains elusive. Several groups are searching for additional breast cancer susceptibility genes using whole genome scanning approaches, but the success of many of these approaches depend on the underlying heterogeneity of the remaining cancer susceptibility loci. The failure to date to identify additional breast cancer susceptibility genes associated with a high risk of disease suggests that more than one may exist. We have taken the approach that the next BRCA genes will be those that encode for proteins whose functions are linked to important cell regulatory pathways. We have recently found one such candidate BRCA3 protein, referred to as BRCC36.
- Medicine and Medical Research