Accession Number:

ADA439851

Title:

Genetic Susceptibility to Prostate Cancer in the Netherlands

Descriptive Note:

Final rept. 1 Aug 2000-31 Jul 2004

Corporate Author:

NEW YORK UNIV NY SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2004-08-01

Pagination or Media Count:

14.0

Abstract:

Studies of the genetics of populations that were historically endogamous for reasons of geography, religion, or language have contributed substantially to our understanding about hereditary predisposition to cancer. One such population is found in the Netherlands where multiple, prevalent, population-specific founder mutations have been identified. Genetic susceptibility to prostate cancer is being investigated in the Netherlands Cohorts Study NLCS on Diet and Cancer, which has identified over 800 cases of prostate cancer among 58,279 male participants. From this study, we have identified 300 cases and 300 controls from men of comparable age to identify markers near prostate cancer susceptibility genes that are present at higher frequency in the group of men with prostate cancer. We optimized the methods for analysis of these markers and observed a candidate region of association on chromosome 1.

Subject Categories:

  • Anatomy and Physiology
  • Geography

Distribution Statement:

APPROVED FOR PUBLIC RELEASE