Non-Classical NF-KappaB Forms and Bc1-3 in Breast Cancer Development and Resistance to Cancer Therapy
Annual rept. 19 May 2004-18 May 2005
NORTH CAROLINA UNIV AT CHAPEL HILL
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Breast cancer development typified by the overexpression of growth factors and growth factor receptors, expression of cell cycle markers such as cyclin D1 and c-myc, expression of chemokines such as RANTES, and development of resistance to cancer therapies. We and others have provided evidence that the transcription factor NF-kappaB and associated activities are expressedactivated in human breast cancer. Specifically we found that the NF-kB2p52 NF-kappaB subunit and Bcl-3 are expressed in a significant number of breast tumors. Other goals were to i identify genes regulated by Her-2neu and Bcl-3 that may be relevant to the progression of the disease, ii determine the mechanism whereby Bcl-3 blocks cancer therapy induce apoptosis, and iii determine if Bcl-3 and the associated NF-kappaB subunit p52 are required for the development of experimental breast tumors in animal models. These goals may provide significant new insight into breast cancer progression and treatment.
- Anatomy and Physiology
- Medicine and Medical Research