Dietary Determinants of Prostate Cancer
Annual summary rept. 1 Mar 2004-28 Feb 2005
CALIFORNIA UNIV BERKELEY LAWRENCE BERKELEY LAB
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Prostate Cancer PCa accounts for nearly 30 of all newly diagnosed cancers among American men. Epidemiologic studies suggest that dietary factors may be important in the etiology of PCa. The objective of our research is to determine how nutritional compounds genistein, betasitosterol STT, and omega-6 fatty acids FA function as modulators of PCa. In the second year of study, we finished preparation of all cDNAs for fabricating the custom microarray for analysis of gene expression. In addition, we completed in vitro and in vivo experiments using well established PCa cell lines and the three dietary compounds in varying concentrations. We are currently in the process of printing and validating the microarray and utilizing the array to detect gene expression patterns from the experiments. Finally, we have initiated xenograft in vivo experiments with a novel PCa model that was developed recently in a collaborating laboratory.
- Anatomy and Physiology
- Medicine and Medical Research