Bioenergetic Approaches and Inflammation in MPTP Toxicity
Annual rept. 1 Sep 2004-31 Aug 2005
CORNELL UNIV MEDICAL COLL (WEILL) NEW YORK
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We wish to continue to examine a number of new neuroprotective agents in the MPTP model of PD, which act by inhibiting the mitochondrial permeability transition MPT We also wish to utilize metabolomic profiling to identify novel biomarkers for PD and to investigate whether these occur in animal models of PD. We will develop and characterize a new animal model of PD making a knockout of PINK1, which is a nuclear-encoded kinase localized to mitochondria, and which causes autosomal recessive PD. Lastly, we wish to study the effects of human dopaminergic stem cells in the 6-hydroxy-dopamine model of PD.
- Medicine and Medical Research