Accession Number:

ADA439248

Title:

Ultrasound Activated Contrast Imaging for Prostate Cancer Detection

Descriptive Note:

Annual rept. 1 Mar 2004-28 Feb 2005

Corporate Author:

THOMAS JEFFERSON UNIV PHILADELPHIA PA

Personal Author(s):

Report Date:

2005-03-01

Pagination or Media Count:

15.0

Abstract:

The current project proposes to develop a novel ultrasound contrast imaging technique called EEI for better visualization of the microvessels, which are characteristic of the neovasculature associated with prostate cancer. The new zero-thickness interface model was used to simulate EEI. While results at an imaging frequency of 7.5 MHz were in reasonable agreement with measurements 3-4 dB enhancement, there, was no agreement for 3 MHz imaging 10 dB measured but no enhancement simulated. Further work is ongoing to improve upon the model. The pulse-echo system was used to perform in vitro EEI measurements at 7.5 MHz. Around 6 dB of enhancement was measured with Optison irrespective of temperature, whereas Sonazoid produced 6 dB of enhancement at 22 deg C and only 3 dB at 37 deg C. Finally, a Logiq 9 scanner with a 3.5C curved linear array and an AN2300 digital ultrasound engine with a P4-2 phased array transducer were modified to perform EEI on a vector-by-vector basis in fundamental and pulse inversion harmonic grayscale modes. A flow phantom with contrast was imaged in vitro. While video intensities of scattered signals from the surrounding tissue were unchanged, video intensities of echoes from contrast bubbles within the vessel were markedly enhanced. The maximum enhancement achieved was 10.4 dB in harmonic mode.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE