Novel Micro/Nano Approaches for Glucose Measurement Using pH-Sensitive Hydrogels
Annual rept. 1 Jun 2004-31 May 2005
LOUISIANA TECH UNIV RUSTON
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This project aims to couple environmentally-sensitive hydrogel materials with immobilized enzymes and two novel readout techniques to develop general platforms for biosensing. The need for improved testing methods for diabetics as well as the potential for use of glucose level as a general marker of metabolic status is the primary motivation for this work. This project is focusing on the use of sensitive transduction schemes that allows reliable detection of small physicalmechanical changes in gel size or water content, specifically microelectromechanical systems MEMS and fluorescence resonance energy transfer RET optical systems. At the completion of one project year, successful demonstrations of glucose sensing have been accomplished in both areas, and interesting discoveries of hydrogel structure and properties have been uncovered using the novel measurement approaches. While the project is ahead of schedule according to the expected milestones for demonstrating sensing capabilities, optimization of sensitivity, range, and stability are key goals for the second project year. The project has generated three manuscripts to be submitted for peer review and four conference reports, with similar products expected for the second year.
- Medicine and Medical Research