Accession Number:

ADA439215

Title:

An MR Contrast Agent for Intra-Prostatic Imaging of Prostatic Cancer

Descriptive Note:

Annual rept.

Corporate Author:

MASSACHUSETTS GENERAL HOSPITAL BOSTON

Personal Author(s):

Report Date:

2005-01-01

Pagination or Media Count:

8.0

Abstract:

An MR contrast agent targeted to the GRP receptor will be a novel pharmaceutical capable of non-invasively, and at high spatial resolution, characterizing healthy and patholological regions within the prostate. The goal of the research is to develop a magnetic nanoparticle MR contrast targeted to the gastrin releasing peptide receptor GRP receptor that will be used to image the intra-prostatic distribution of this key molecular marker. Because of technical problems in imaging the GRP receptor in animal models of prostate cancer, we have been imaging the expression of this receptor in the normal mouse pancreas Our long term goal is to use this animal model to refine our understanding of the interaction of magnetic nanoparticles with this receptor and return to the animal prostate cancer models.

Subject Categories:

  • Medicine and Medical Research
  • Nuclear Physics and Elementary Particle Physics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE