Accession Number:

ADA439170

Title:

Targeted Gene Therapy for Breast Cancer

Descriptive Note:

Annual summary rept. 1 Jun 2002-31 May 2005

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM

Personal Author(s):

Report Date:

2005-06-01

Pagination or Media Count:

24.0

Abstract:

During the last three years of support of the career development award, we sought to develop and evaluate recombinant adeno-associated virus vectors encoding anti- angiogenic factors. We have completed the work with significant outcome, and also initiated new studies that will allow us to test novel possibilities for breast cancer treatment. The outcome of the present studies strongly indicated that sustained expression of anti-angiogenic factors not only provide significant growth inhibition of localized cancer in mouse model but also exerted tumor-free survival in combination with chemotherapy. We have also identified that the effect of anti-angiogenic therapy with rAAV in combination with chemotherapy, was independent of surviving pathway. Histopathological analysis of major visceral organs and liver enzyme analysis also revealed no toxicity because of combination therapy.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE