A System for Discovering Bioengineering Threats by Knowledge Base Driven Mining of Toxin Data
Annual rept. 1 Aug 2004-31 Jul 2005
BROOKHAVEN NATIONAL LAB UPTON NY
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The overall goal of this project is to establish a Toxin Knowledge Base TKB a bioinformatics resource primarily focused on molecular information about toxins and other virulence factors that are the natural products of biological and potential biological warfare RW and PBW agents. The resource will be mined to assimilate synthesize, analyze and disseminate genomic and structural information on BW and PBW genes and their products. The TKB will be designed and developed to serve as a powerful analysis and decision system tool for the intelligence community. In this first annual report we describe in detail the TKB system that we have developed that can be used to identify homologs of toxins. The TKB contains molecular, biological and structural information of about 1000 toxins and is still being expanded. TKB will also use innovative computer methods to parse the literature available in public resources web sites to identify new and emerging toxins to be included in the database.
- Mining Engineering
- Military Operations, Strategy and Tactics