A Novel Member of the Insulin-Like Growth Factor Binding Protein Superfamily in Prostate Cancer
Final rept. 1 Feb 2000-31 Jan 2004
OREGON HEALTH SCIENCES UNIV PORTLAND
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The insulin-like growth factors IGFs are potent mitogens for normal and cancerous prostatic cells. The IGFs are found complexed to IGF binding proteins IGFBPs which modulate IGF bioactivity, but also may themselves act in an IGF-independent manner. We have recently characterized a series of IGFBP-related proteins IGFBP-rPs which share homology with the IGFBPs in the amino-terminus, bind IGFs with low affinity, and regulate cell growth through both IGF-dependent and IGF-independent actions. This grant is directed at the study of IGFBP-rPs also known as connective tissue growth factor as a regulator of normal and malignant prostatic growth. The specific aims are to 1 analyze IGFBP-rPs mRNA and protein expression and distribution in normal and malignant prostatic tissues 2 determine the transcriptional, translational and post-translational regulation of IGFBP-rPs and 3 determine the mechanisms by which IGFBP-rPs regulates prostatic growth.
- Medicine and Medical Research