Accession Number:

ADA438021

Title:

Bacillus anthracis Edema Toxin Inhibits Staphylococcus aureus Enterotoxin B Effects in Vitro: A Potential Protein Therapeutic?

Descriptive Note:

Journal article

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD

Personal Author(s):

• Krakauer, Teresa
• Little, Stephen F.
• Stiles, Bradley G.

Report Date:

2005-10-01

Pagination or Media Count:

6.0

Abstract:

Various in vitro effects of staphylococcal enterotoxin B SEB on human peripheral blood mononuclear cells were mitigated by Bacillus anthracis edema toxin. In particular, levels of some SEB-induced cytokines tumor necrosis factor alpha, gamma interferon and chemokines monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha MIP-1alpha, MIP-1beta were significantly diminished or even nonexistent, depending upon the timing of edema toxin administration. Overall, these results suggest a novel use of B. anthracis edema toxin against a bacterial superantigen.

Descriptors:

• *ENTEROTOXINS
• *BACILLUS ANTHRACIS
• *EDEMA
• IN VITRO ANALYSIS
• ANTHRAX
• CYTOKINES
• ANTIGENS
• STAPHYLOCOCCUS
• EXOTOXINS
• BLOOD CELLS

Subject Categories:

• Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE