Accession Number:

ADA437633

Title:

Potentiation of T Lymphocyte Responses by Modulating NF-kB Activity in Dendritic Cells

Descriptive Note:

Annual rept. 1 May 2003-30 Apr 2004

Corporate Author:

COLUMBIA UNIV NEW YORK

Personal Author(s):

• Beg, Amer A.

Report Date:

2004-06-01

Pagination or Media Count:

5.0

Abstract:

The goal of this investigation is to determine whether modulation of NF-kappa beta activity by genetic engineering of DCs can affect DC longevity and T cell stimulatory functions. The specific aims are 1 To determine the effect of expression of constitutively-active IK beta I kappa beta kinase on nuclear NF-kappa beta levels in DCs, and on the longevity of DCs. 2 To determine beta expression on in vitro and in vivo T cell priming by DCs. Results from these studies may thus lead the way for development of approaches for enhancing DC survival and function, with the goal of generating potent anti-tumor immunity.

Descriptors:

• *T LYMPHOCYTES
• *GENETIC ENGINEERING
• *DENDRITIC STRUCTURE
• NEOPLASMS
• SURVIVAL(PERSONNEL)
• DIRECT CURRENT
• IMMUNITY
• IN VITRO ANALYSIS
• RESPONSE(BIOLOGY)

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE