Case Series Investigation of Amyotrophic Lateral Sclerosis (ALS) Among Former Kelly Air Force Base Workers
OAK RIDGE INST FOR SCIENCE AND EDUCATION TN
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Concerns over a possible cluster of amyotrophic lateral sclerosis ALS among former workers at Kelly Air Force Base - Kelly AFB prompted a series of scientific investigations. In an attempt to gain insight into the occupational, environmental and lifestyle exposure histories of persons with ALS PALS, the ALS Association-South Texas Chapter and the Air Force Institute for Operational Health AFIOH, formerly the Air Force Institute for Environment, Safety, and Occupational Health Risk Analysis, or AFIERA collaborated on a case series investigation of persons linked to Kelly AFB who reported having ALS. In all, ninety-three PALS returned questionnaires that were included in the final analysis. Using reported prevalence figures as a comparison, PALS appeared similar to other ALS cases and U.S. adults for ALS disease course, recreational, immunization, infectiontrauma, tobacco use, alcohol use, and family medical histories. Historically, these cases may have been more physically active than other ALS case series and U.S. adults, perhaps due to a healthy worker or healthy soldier effect. The limitations of the study, including the highly heterogeneous population, amount of proxy report, absence of a control group, length of the questionnaire, and use of generalized comparison figures, must be considered when discussing and interpreting the results.
- Medicine and Medical Research