Accession Number:

ADA436125

Title:

National Department of Defense Surveillance for Clinical Group A Streptococcal Isolates, Antibiotic Resistance, and emm Gene Types from 8 Basic Training Military Sites

Descriptive Note:

Rept. for Jan 1998-Dec 2002

Corporate Author:

NAVAL HEALTH RESEARCH CENTER SAN DIEGO CA

Personal Author(s):

• Barrozo, Christopher P.
• Russell, Kevin L.
• Smith, Tyler C.
• Hawksworth, Anthony W.
• Ryan, Margaret A.
• Gray, Gregory C.

Report Date:

2003-01-08

Pagination or Media Count:

22.0

Abstract:

Active surveillance for group A streptococci GAS was conducted among military trainees with pharyngitis at 8 U.S. military basic training sites between January 1998 and December 2001. Antibiotic resistance and emm gene type distribution were assessed for 692 GAS isolates. Antibiotic susceptibility testing revealed 100 sensitivity to penicillin, levofloxacin and vancomycin. Forty-four isolates 6.4 were resistant to erythromycin, 38 5.5 resistant to tetracycline, 22 3.2 resistant to clindamycin, and 14 isolates 2.0 showed multidrug resistance. The most prevalent genotypes were emm29 18.0, emm3 15.2, emm6 13.5, emm4461 9.1, emm2 7.3, emm75 6.4, and emm1 4.8. An association was found among distinct emm types and geographic location. Erythromycin resistance was strongly associated with emm75 and emm29 isolates p 0.001. Continued monitoring of antibiotic susceptibility and genetic epidemiology of GAS isolates is important for directing appropriate prevention and treatment strategies among U.S. military populations.

Descriptors:

• *STREPTOCOCCUS
• *ANTIBIOTICS
• *RESISTANCE(BIOLOGY)
• *DRUG TOLERANCE
• MILITARY PERSONNEL
• CLINICAL MEDICINE
• MOLECULAR BIOLOGY
• TRAINEES
• GEOGRAPHY
• GENETICS
• EPIDEMIOLOGY
• TETRACYCLINES
• PENICILLINS
• ERYTHROMYCIN
• VANCOMYCIN

Subject Categories:

• Genetic Engineering and Molecular Biology
• Microbiology
• Pharmacology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE