Accession Number:

ADA435748

Title:

On-Chip Hardware for Cell Monitoring: Contact Imaging and Notch Filtering

Descriptive Note:

Final rept. 16 Apr 2004-7 Jul 2005

Corporate Author:

MARYLAND UNIV COLLEGE PARK

Report Date:

2005-07-07

Pagination or Media Count:

7.0

Abstract:

The cell canary system will combine live bio-engineered cells with on-chip MEMS hardware. It will function by monitoring the response of many live cells to an external environment. Each cell, or cell colony, will be bio-engineered to fluoresce in response to a specific external pathogen. The fluorescence will occur through a FRET interaction with a quantum dot that labels a component of the pathway. If the cell or cell colony dies due to the presence of its target pathogen, then it will fluoresce as it dies if the cell or cell colony dies due to other factors, then it will not fluoresce. The system will therefore act as a cell canary system for specific, low-false-positive detection of pathogens. Our goal here is to demonstrate proof-of-concept for the on-chip fluorescence detection portion of the project.

Subject Categories:

  • Electrical and Electronic Equipment
  • Optics
  • Quantum Theory and Relativity

Distribution Statement:

APPROVED FOR PUBLIC RELEASE