The Effects of Stress and Nicotine on Heart Histopathology Differ in Male and Female Sprague-Dawley and Long-Evans Rats
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD DEPT OF MEDICAL AND CLINICAL PSYCHOLOGY
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This experiment investigated the effects of nicotine for 14 days 0, 6, or 12 mgkgday and immobilization stress on heart histopathology in 120 male and 120 female rats of two strains Sprague-Dawley and Long-Evans. Results show that both nicotine and stress affected heart tissue, including heart mass and wall thickness. These effects differed between males and females. Females were more sensitive than males to the effects of nicotine on heart histopathology. In contrast, males were more sensitive than females to the effects of stress. The effects of nicotine also differed between the Sprague-Dawley and Long-Evans rats. The hearts of the Long-Evans rats were more affected by both nicotine and stress than were the Sprague-Dawley rats. These findings have important implications for understanding the cardiotoxic effects of both nicotine and stress and could be used to further elucidate the mechanisms by which stress and nicotine separately contribute to heart disease.
- Anatomy and Physiology
- Medicine and Medical Research