Accession Number:

ADA434827

Title:

Effects of Nicotine Administration, Cessation, and Differential Housing Conditions on Aggressive Behaviors of Male and Female Rats

Descriptive Note:

Master's thesis

Corporate Author:

UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD

Personal Author(s):

Report Date:

1997-01-01

Pagination or Media Count:

90.0

Abstract:

The present experiment examined effects of nicotine administration, nicotine cessation, and two housing conditions individuals vs. grouped on social interaction and serum testosterone in Long-Evans rats. Nicotine reduced aggressive behavior of male and female rates, particularly in single-house conditions. Effects of f nicotine on serum testosterone in males also depended on housing condition with nicotine reducing serum testosterone of single-housed males but not group-housed males. In addition, single-housed males and females exhibited more aggressive behaviors than group-housed animals. Male testosterone levels and aggressive behaviors returned to baseline during nicotine cessation. The results suggest that effects of nicotine may be modified by environmental or social situations. Further, for male subjects, aggressive behavior were accounted for by housing and drug conditions rather than by testosterone levels.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE