Effects of Nicotine and Nicotinic Antagonists on the Acoustic Startle Response and on Pre-Pulse Inhibition in Rats
UNIFORMED SERVICES UNIV OF THE HEALTH SCIENCES BETHESDA MD
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In rats, nicotine has effects on the amplitude of the acoustic startle response ASR and on pre-pulse inhibition of the acoustic startle response PPI that are consistent with an inverted U-shaped dose-effect. Because ASR and PPI have been used to study processes that underlie attention and sensory gating, these effects of nicotine in rats are viewed as consistent with reports that nicotine can enhance attention in human smokers. However, the mechanisms underlying these affects of nicotine have not been identified. The purpose of the present experiment was to determine whether nicotines affects on ASR and PPI are a result of its effects in the central nervous system or if nicotines effects on ASR and PPI are due to its effects peripherally.
- Medicine and Medical Research