Accession Number:

ADA434813

Title:

Non-Immunogenic Structurally and Biologically Intact Tissue Matrix Grafts for the Immediate Repair of Ballistic-Induced Vascular and Nerve Tissue Injury in Combat

Descriptive Note:

Annual rept. 15 Nov 2003-14 Nov 2004

Corporate Author:

LIFECELL CORP BRANCHBURG NJ

Personal Author(s):

• Bachrach, Nathanial

Report Date:

2004-12-01

Pagination or Media Count:

74.0

Abstract:

In the first two years of this work the production of decellularized and freeze-dried vascular grafts from human umbilical vessels was accomplished while substantially maintaining tissue microstructure biological activity and biomechanical properties. It was anticipated that umbilical vein and artery grafts implanted clinically would demonstrate patency as well as significant repopulation and remodeling by the surrounding host tissue. Such a graft would be a desirable alternative to current interventions for hemodialysis access occluding non-remodeling synthetic PTFE grafts and inconsistent native fistulas, below-the-knee vessel replacement amputation, and coronary artery bypass grafting.

Descriptors:

• *NERVES
• *SKIN GRAFTS
• *BIOLOGICAL WARFARE CASUALTIES
• TISSUES(BIOLOGY)
• FREEZE DRYING
• MEDICAL SERVICES
• CARDIOVASCULAR SYSTEM
• BIOMECHANICS
• BLOOD VESSELS
• HOSTS(BIOLOGY)
• ARTERIES
• CORONARY ARTERIES
• SURGICAL TRANSPLANTATION

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research
• Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE