Accession Number:

ADA434612

Title:

Preliminary Investigation of the Role of Cellular Immunity in Estrous Cycle Modulation of Post-Resection Breast Cancer Spread

Descriptive Note:

Final rept. 20 Apr 1998-3 Jul 2004

Corporate Author:

DORN RESEARCH INST INC COLUMBIA SC

Personal Author(s):

Report Date:

2004-08-01

Pagination or Media Count:

53.0

Abstract:

The timing of resection of a transplantable breast cancer within the mouses estrous cycle affects whether the cancer metastasizes or whether the operation cures the mouse. Surgery during the pro-estrus phase cured 2 12 times more frequently than the opposite timing. The authors have studied the immune capacity of the mouse to generate natural killer NK cell activity. Surgical curability was optimal during pro-estrus when immunocompetence was most robust. Enhancing NK function diminishes metastatic spread while interfering with NK function increases spread. Estrogens diminish NK function. The authors plan to determine whether hormone-dependent immunocyte suppression affects fertility cycle modulation of cancer spread which female sex hormones control post-resection spread whether estrogen andor progesterone affect the duration of NK cell activity suppression and numbers of NK, helper T, andor suppressor T cells following resection and whether deleting specific immune cell types by in vivo administration of antibodies abrogates the estrous cycle and sex hormone modulation of post-resection cancer spread. Demonstration that NK, T helper, andor T suppressor cells are essential for sex hormone modulation of cancer spread would implicate neo-adjuvant sex hormone and other cellular immune enhancement strategies before andor following breast cancer resection to improve cure frequency.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE