Accession Number:

ADA434360

Title:

Humanizing the Mouse Androgen Receptor to Study Polymorphisms and Mutations in Prostate Cancer

Descriptive Note:

Annual rept. 31 Dec 2003-30 Dec 2004

Corporate Author:

MICHIGAN UNIV ANN ARBOR

Personal Author(s):

Report Date:

2005-01-01

Pagination or Media Count:

14.0

Abstract:

Androgen receptor AR is a critical component in prostrate oncogenesis. AR alleles varying in length of the Nterminal glutamine Q tract carry distinct disease risks. Mutation of AR in tumors may influence androgen independence and resistance to treatment. Difficulties studying cancer initiation and progression are partly overcome with transgenic mouse tumor models. However, the mouse AR N-terminus differs significantly from human.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE