Multifunctional Magnetic Nanoparticle Probes for Deep-Tissue Imaging
Final technical rept. 1 May 2003-31 Oct 2004
EMORY UNIV ATLANTA GA
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The goal of the DARPA-AFOSR project is to develop multifunctional magnetic nanoparticle probes for deep-tissue imaging using MRI. The specific objectives of the Phase 1 project include 1 to functionalize iron-oxide magnetic nanoparticles for bioconjugation of oligonucleotides and peptides 2 proof-of-concept demonstration of the signal transduction mechanism based on nanoprobe clustering on mRNA target 3 to develop peptide-based delivery of magnetic nanoprobes into living cells with high delivery efficiency 4 to perform preliminary MRI studies of detection sensitivity and signal-to-noise ratio in solution and in cells. This innovative molecular imaging approach integrates in vivo delivery, targetingsensing and signal transduction it has the potential to revolutionize medical imaging, diagnosis, and therapeutics with many DoD applications.
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