Accession Number:

ADA434070

Title:

Phase I Trial of Adenovirus-Mediated IL-12 Gene Transduction in Patients With Radiorecurrent Prostate Cancer

Descriptive Note:

Annual rept. 9 Sep 2003-8 Sep 2004

Corporate Author:

MOUNT SINAI SCHOOL OF MEDICINE NEW YORK

Personal Author(s):

Report Date:

2004-10-01

Pagination or Media Count:

17.0

Abstract:

Patients with radiorecurrent prostate cancer have few options. Gene therapy may define a treatment option of both local and systemic value. Pre-clinical studies using adenovirus-mediated Ad transduction of IL-12 Ad.mIL-12 in metastatic model of prostate cancer resulted in local growth suppression, survival enhancement and inhibition of pre-established metastases. The basis for these activities include the induction of both innate neutrophils NKs and acquired immunity T cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE