Accession Number:

ADA433991

Title:

Identifying Early Diagnosis Markers of Prostate Cancer

Descriptive Note:

Annual rept. 1 Jul 2003-30 Jun 2004

Corporate Author:

SCRIPPS RESEARCH INST LA JOLLA CA DEPTOF MOLECULAR BIOLOGY

Personal Author(s):

Report Date:

2004-07-01

Pagination or Media Count:

7.0

Abstract:

The successful treatment of prostate cancer requires detection of the disease at early stages. Currently the early diagnosis of prostate cancer largely depends on the detection of prostate-specific antigen PSA in circulation. However, PSA can only precisely detect 40 of prostate cancer and is not specific for the occurrence of prostate cancer. We reasoned that the success and accuracy in early diagnosis of prostate cancer may be significantly improved if a panel of prostate cancer-specific markers can be identified and used in combination for detecting early stage of prostate cancer. Our proposal aims to identify a panel of secretion proteins overproduced in early stage prostate tumors. We believe that some of these proteins can be potential candidate biomarkers for the early diagnosis of prostate cancer. Through subsequent studies that are beyond the scope of this proposal, these proteins can be further analyzed for their value as early diagnostic markers for breast cancer.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE