Center for the Evaluation of Biomarkers for the Early Detection of Breast Cancer
Annual rept. 23 Sep 2003-22 Sep 2004
FRED HUTCHINSON CANCER RESEARCH CENTERSEATTLE WA
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Breast Cancer remains a leading cause of death for women in the U.S. despite the popularity of mammography as a preventive tool. At diagnosis, many breast cancers are at an advanced stage of disease, even for women undergoing yearly screening, resulting in costly and painful follow-up procedures. Based on the ongoing studies in many research institutions, it has been shown that molecular markers can increase our ability to diagnose early stages tumors, This has been demonstrated by current clinical practices using the CA-125 marker and PSA for the detection of ovarian and prostate cancer, respectively. The purpose of this study is to search for breast cancer biomarkers and evaluate their effectiveness in detecting early stage carcinoma. by combining molecular diagnosis with current imaging analysis of breast tissue, we may further reduce the number of deaths as well as the number of women undergoing surgery and chemotherapy due to breast cancer. To date, we have created the infrastructure necessary for our interdisciplinary team of investigators to obtain study samples, characterize candidate biomarkers, and efficiently communicate research findings. We have also increased the number of potential biomarkers and looked into more efficient and sensitive biotechnology that may better assist our study investigators.
- Medicine and Medical Research