Accession Number:

ADA433934

Title:

Temporal and Spatial Dynamics of DNA Topoisomerase I in Prostate Cancer

Descriptive Note:

Annual rept. 15 Dec 2003-14 Dec 2004

Corporate Author:

MISSISSIPPI UNIV UNIVERSITY

Personal Author(s):

Report Date:

2005-01-01

Pagination or Media Count:

9.0

Abstract:

The purpose of this proposal was to investigate the response of prostate cancer to a series of camptothecin analogs, which are drugs that target DNA topoisomerase I. Toward task 1 of our proposal, we used immunofluorescence staining. However, this did not provide satisfactory results due to non-specificity of the rabbit serum used. We focused predominantly on tasks related to the data obtained from the completed task 3. We developed a very potent camptothecin analog that shows good activity in prostate cancer.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE