Inhibitors of Histone Deacetylases for Radiosensitization of Prostate Cancer
Annual rept. 12 Jan 2004-11 Jan 2005
GEORGETOWN UNIV WASHINGTON DC MEDICAL CENTER
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Failure of conventional treatment of prostate cancer with radiotherapy may be due to the intrinsic resistance of the tumor cells. One of mechanisms underlying intrinsic radiation sensitivity is linked to the state of chromatin architecture. The long-term goal of this proposal is to develop a novel therapeutic strategy by enhancing radio sensitivity of prostate cancer cells by testing the hypothesis that an increase of cellular radiation sensitivity may be achieved by exposure of cells to specific histone deacetylase HDAC inhibitors. During the first year of the research the major accomplishments were as follows 1 determination of the values of 50 HDAC inhibition activities of newly synthesized HDAC inhibitors and their anti-proliferation activities, and 2 determination of the efficacy of HDAC inhibitors on cellular radiation sensitivity. An 8-page journal article, Cytoplasmic Sequestration of HDAC7 from Mitochondrial and Nuclear Compartments upon Initiation of Apoptosis by Robert E. Bakin and Mira O. Jung, is included.