Accession Number:

ADA433882

Title:

Unique Approaches to Androgen Effects on Prostate Cancer

Descriptive Note:

Annual rept. 19 Jan 2004-18 Jan 2005

Corporate Author:

SAINT LUKE'S-ROOSEVELT INST FOR HEALTH SCIENCES NEW YORK NY OFFICE OF GRANTSAND RESEARCH ADMINISTRATION

Personal Author(s):

Report Date:

2005-02-01

Pagination or Media Count:

13.0

Abstract:

Sex hormone-binding globulin SHBC is a plasma protein that binds androgens. It also is a transducer of androgen signaling at the plasma membrane of prostate cancer cells. We have found that the human prostate cancer cell line, LNCaP, in addition to having a receptor for SHBG RsHBG, produces its own SHBG. We hvpothesize that local regulation of SHBG production andor secretion results in important autocrine and paracrine effects that influence gene expression and growth in prostate cancer cells.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE