Role of PSMA in Aberrant Cell Cycle Progression in Prostate Cancer
Annual rept. 1 Dec 2003-30 Nov 2004
CALIFORNIA UNIV LOS ANGELES
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Prostate specific membrane antigen PSMA is a well-studied, highly restricted prostate epithelial cell membrane antigen. In contrast to other highly restricted prostate-related antigens such as prostate specific antigen PSA and prostatic acid phosphatase PAP, which are secretory proteins, PSMA is an integral membrane protein. In addition to its prostate specificity, PSMA is expressed by a very high proportion of prostate cancers Pca, expression is further increased in higher grade cancers, in metastatic disease, and in hormone-refractory PCa. Among reasons for significant interest in PSMA is that it is ideal for in vivo prostate-specific targeting strategies. Although PSMA is primarily localized to the plasma membrane immunofluorescence analysis also revealed its localization to a membrane compartment around the centrosome. Consistent with its localization around the centrosomes PSMA expressing cells rapidly exited mitosis. We have now determined that the association 6 the cytoplasmid tail of PSMA with key regulators of cell cycle progression is involved the aberrant mitotic exit of PSMA expressing cells.
- Medicine and Medical Research