Accession Number:

ADA433856

Title:

Role of ei24/PIG8, A Putative Pro-Apoptotic Tumor Suppressor, in Breast Cancer Development and Resistance to Drug Therapy

Descriptive Note:

Annual rept. 1 Mar 2004-28 Feb 2005

Corporate Author:

BOSTON UNIV MA

Personal Author(s):

Report Date:

2005-03-01

Pagination or Media Count:

13.0

Abstract:

EI24PIG8 is regulated by p53 in response to genotoxic damage and was shown to be genetically inactivated in aggressive breast cancers with frequent loss-of-heterozygosity. In addition, it was shown that ectopic expression of EI24P108 resulted in apoptosis, whereas suppression of E124PIO8 expression resulted in increased survival after treatment with an apoptotic retinoid. We hypothesizid that genetic inactivation of EI24PIO8 is a major contributing factor to breast cancer development and resistance to chemotherapeutic agents such as etoposide. We recently found evidence that EI24PIO8 directly binds with Bcl-2 in the endoplasmatic reticulum ER, and likely initiates apoptosis at this organelle by altering the activity of ER-resident Bcl-2 purpose of Objectives 1 and 2. Our studies also showed that EI24PIG8 likely serves to suppress tumor spreading, rather than formation of the primary tumor. Thus, the EI24PI08 status of breast cancers may serve as a potential novel prognostic indicator in this disease.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE